Selenoprotein P. Its Structure and Functions.
نویسندگان
چکیده
منابع مشابه
Domain structure of bi-functional selenoprotein P.
Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the remaining nine localized in the C-terminal third part. We have shown that SeP not only catalyses the reduction of phosphatidylcholine hydroperoxide by glutathione [Saito, Hayashi, Tanaka, Watanabe, Suzu...
متن کاملDirect Interaction between Selenoprotein P and Tubulin
Selenium (Se), an essential trace element for human health, mainly exerts its biological function via selenoproteins. Among the 25 selenoproteins identified in human, selenoprotein P (SelP) is the only one that contains multiple selenocysteines (Sec) in the sequence, and has been suggested to function as a Se transporter. Upon feeding a selenium-deficient diet, mice lacking SelP develop severe ...
متن کاملSelenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p.
Selenoprotein P is an extracellular protein containing presumably 10 selenocysteines that are encoded by the UGA stop codon in the open reading frame of the mRNA. The function of selenoprotein P is currently unknown, although several indirect lines of evidence suggest that selenoprotein P is a free radical scavenger. We first developed a conventional procedure to isolate selenoprotein P from hu...
متن کاملConserved features of selenoprotein P cDNA.
26. Berry, M. J., Banu, L., Harney, J. W. and Larsen, P. R. (1993) EMBO J. 12,3315-3322 Said, €3. Cole, J. K. and Nornura, M. (1988) Nucleic Acids Res. 16, 10529-10545 Cerretti, 1). P., Mattheakis, I,. C., Kearney, K. K., Vu, 1,. and Nomura, M. (1988) J. Mol. Biol. 204, 309-325 Rould, M. A,, Perona, J. J. and Steitz, T. A. (1991) Nature (London) 352,2 13-2 18 Bettany, A. J. E., Eisenstein, R. S...
متن کاملSEPP 1 ( selenoprotein P , plasma , 1 )
Note SEPP1 belongs to selenoproteins, all of which contain selenium in the form of selenocysteine (SeC) and are being synthesized in the presence of UGA codon, specific stem loop structure in 3' UTR of mRNA called SECIS (Selenocysteine Insertion Sequence) and other specific factors. Selenoprotein P is a glycoprotein present mainly in plasma, where it accounts for 40 65% of total selenium in thi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2000
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.46.409